abstract：:Chemokines are increasingly recognised as playing a role in depression. Here we meta-analyse the data on concentrations of all chemokines in patients diagnosed with a major depression versus healthy controls. We included studies which utilised Diagnostic and Statistical Manual (DSM)-IV diagnostic criteria for major de...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Eyre HA,Air T,Pradhan A,Johnston J,Lavretsky H,Stuart MJ,Baune BT

更新日期：2016-07-04 00:00:00

abstract：:Major depression (MDD) is a chronic psychiatric condition in which patients often show increasing cognitive impairment with recurring episodes. Neurodegeneration may play an important component in the pathogenesis of MDD associated with cognitive complaints. In agreement with this, patients with MDD show decreased bra...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kim HK,Nunes PV,Oliveira KC,Young LT,Lafer B

更新日期：2016-06-03 00:00:00

abstract：:5-HT2Rs have a different genomic organization from other 5-HT2Rs. 5HT2CR undergoes post-transcriptional pre-mRNA editing generating diversity among RNA transcripts. Selective post-transcriptional editing could be involved in the pathophysiology of psychiatric disorders through impairment in G-protein interactions. Mor...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Chagraoui A,Thibaut F,Skiba M,Thuillez C,Bourin M

更新日期：2016-04-03 00:00:00

abstract：:The ZEB2 gene encodes the Zinc Finger E-box binding protein. As a key regulator of epithelial mesenchymal differentiation, ZEB2 plays an important role in the pathogenesis of cancer, and its high level expression has been observed in glioma patients. Different mutations in this gene have been identified in patients wi...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Khan RAW,Chen J,Wang M,Li Z,Shen J,Wen Z,Song Z,Li W,Xu Y,Wang L,Shi Y

更新日期：2016-04-03 00:00:00

abstract：:White matter abnormalities have been described in autism spectrum disorder (ASD) with mounting evidence implicating these alterations in the pathophysiology of the aberrant connectivity reported in this disorder. The goal of this investigation is to further examine white matter structure in ASD using proton magnetic r...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Hardan AY,Fung LK,Frazier T,Berquist SW,Minshew NJ,Keshavan MS,Stanley JA

更新日期：2016-04-03 00:00:00

abstract：:Higher impulsivity observed in alcoholics is thought to be due to neurocognitive functional deficits involving impaired inhibition in several brain regions and/or neuronal circuits. Event-related oscillations (EROs) offer time-frequency measure of brain rhythms during perceptual and cognitive processing, which provide...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Pandey AK,Kamarajan C,Manz N,Chorlian DB,Stimus A,Porjesz B

更新日期：2016-02-04 00:00:00

abstract：UNLABELLED:The capacity to discriminate between safety and danger is fundamental for survival, but is disrupted in individuals with posttraumatic stress disorder (PTSD). Acute stressors cause a release of serotonin (5-HT) in the forebrain, which is one mechanism for enhanced fear and anxiety; these effects are mediated...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Foilb AR,Christianson JP

更新日期：2016-02-04 00:00:00

abstract：:Depression is a serious and potentially life-threatening mental disorder with unknown etiology. Emerging evidence shows that brain-derived neurotrophic factor (BDNF) and microRNAs (miRNAs) play critical roles in the etiology of depression. However, the molecular mechanisms are not fully understood. Expression of miR-1...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Li Y,Li S,Yan J,Wang D,Yin R,Zhao L,Zhu Y,Zhu X

更新日期：2016-02-04 00:00:00

abstract：:Behavior sensitization is a long-lasting enhancement of locomotor activity after exposure to psychostimulants. Incubation of sensitization is a phenomenon of remarkable augmentation of locomotor response after withdrawal and reflects certain aspects of compulsive drug craving. However, the mechanisms underlying these ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wu J,Zhu D,Zhang J,Li G,Liu Z,Sun J

更新日期：2016-02-04 00:00:00

abstract：:Dietary antioxidants might exert an important role in the aging process by relieving oxidative damage, a likely cause of age-associated brain dysfunctions. This study aims to investigate the influence of esculetin (6,7-dihydroxycoumarin), a naturally occurring antioxidant in the diet, on mood-related behaviors and cog...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Martín-Aragón S,Villar Á,Benedí J

更新日期：2016-02-04 00:00:00

abstract：INTRODUCTION:Alcohol dependence is characterized by a reduction in reward threshold, development of a negative affective state, and significant cognitive impairments. Dependence-induced glutamatergic neuroadaptations in the neurocircuitry mediating reward, affect and cognitive function are thought to underlie the neura...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Burnett EJ,Chandler LJ,Trantham-Davidson H

更新日期：2016-02-04 00:00:00

abstract：:The term "drug of abuse" is highly contextual. What constitutes a drug of abuse for one population of patients does not for another. It is therefore important to examine the needs of the patient population to properly assess the status of drugs of abuse. The focus of this article is on the bidirectional relationship b...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Mursaleen LR,Stamford JA

更新日期：2016-01-04 00:00:00

abstract：:Neuromodulation with pharmacological agents, including drugs of abuse such as amphetamine, when paired with behavioral experience, has been shown to positively modify outcomes in animal models of stroke. A number of clinical studies have tested the efficacy of a variety of drugs to enhance recovery of language deficit...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Walker-Batson D,Mehta J,Smith P,Johnson M

更新日期：2016-01-04 00:00:00

abstract：:Over the last decade there has been an explosion of new drugs of abuse, so called legal highs or novel psychoactive substances (NPS). Many of these abused drugs have unknown pharmacology, but their biological effects can be anticipated from their molecular structure and possibly also from online user reports. When con...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Davidson C,Schifano F

更新日期：2016-01-04 00:00:00

abstract：:Addictive disorders are very common and have devastating individual and social consequences. Currently available treatment is moderately effective at best. After many years of neglect, there is renewed interest in potential clinical uses for classic hallucinogens in the treatment of addictions and other behavioral hea...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Bogenschutz MP,Johnson MW

更新日期：2016-01-04 00:00:00

abstract：:Ketamine has been available for approximately 50 years as an anesthetic agent. It is known to have potent effects on the central nervous system glutamatergic system, in particular blockade of N-methyl-D-aspartate (NMDA) receptors. Based upon pre-clinical evidence of involvement of the glutamatergic system in mood diso...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Rasmussen KG

更新日期：2016-01-04 00:00:00

abstract：:There has been significant recent progress in understanding the neurobiological mechanisms of antidepressant treatments. The delayed-onset of action of monoamine-based antidepressant drugs have been associated to their ability to slowly increase synaptic plasticity and neuronal excitability via altering neurotrophic s...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Rantamäki T,Yalcin I

更新日期：2016-01-04 00:00:00

abstract：:Cytokines are pleiotropic molecules with important roles in inflammatory responses. Pro-inflammatory cytokines and neuroinflammation are important not only in inflammatory responses but also in neurogenesis and neuroprotection. Sustained stress and the subsequent release of pro-inflammatory cytokines lead to chronic n...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kim YK,Na KS,Myint AM,Leonard BE

更新日期：2016-01-04 00:00:00

abstract：:Postnatal administration of phencyclidine (PCP) in rodents causes major disturbances to neurological processes resulting in severe modifications to normal behavioral traits into adulthood. It is routinely used to model psychiatric disorders such as schizophrenia, producing many of the dysfunctional processes in the br...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Andrews JL,Newell KA,Matosin N,Huang XF,Fernandez-Enright F

更新日期：2015-12-03 00:00:00

abstract：:Kainic acid (KA)-induced brain neuronal cell death (especially in the hippocampus) was shown to be mainly mediated by the intrinsic (mitochondrial) apoptotic pathway. This study investigated the regulation of the extrinsic apoptotic pathway mediated by Fas ligand/Fas receptor and components of the indispensable death-...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Keller B,García-Sevilla JA

更新日期：2015-12-03 00:00:00

abstract：:Kappa opioid receptors (KORs) in the central nervous system have been known to be important regulators of a variety of psychiatry illnesses, including anxiety and addiction, but their precise involvement in these disorders is complex and has yet to be fully elucidated. Here, we briefly review the pharmacology of KORs ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Crowley NA,Kash TL

更新日期：2015-10-01 00:00:00

abstract：:NVL (nuclear VCP (valosin containing protein)/p97-Like), a member of the AAA-ATPase (ATPases associated with various cellular activities) family, encodes a novel hTERT (human telomerase reverse transcriptase)-interacting protein NVL2 which is a telomerase component essential for holoenzyme assembly. Previous researche...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wang M,Chen J,He K,Wang Q,Li Z,Shen J,Wen Z,Song Z,Xu Y,Shi Y

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:Internet gaming disorder (IGD) shares core clinical features with other addictive disorders, such as gambling disorder and substance use disorder. Designation of IGD as a formal disorder requires elucidation of its neurobiological features and comparison of these with those of other addictive disorders. The a...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Kim H,Kim YK,Gwak AR,Lim JA,Lee JY,Jung HY,Sohn BK,Choi SW,Kim DJ,Choi JS

更新日期：2015-07-03 00:00:00

abstract：INTRODUCTION:Bipolar disorder type I (BD-I) is characterized by a severe impairment in emotional processing during both acute and euthymic phases of the illness. The aim of the present study was to investigate negative emotion processing in both euthymic patients and non-affected first-degree relatives, looking for sta...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Sepede G,De Berardis D,Campanella D,Perrucci MG,Ferretti A,Salerno RM,Di Giannantonio M,Romani GL,Gambi F

更新日期：2015-07-03 00:00:00

abstract：:Group II metabotropic glutamate receptor (mGluR2/3) agonists once showed promise as non-dopaminergic antipsychotic drugs because of their efficacy in alleviating symptoms of schizophrenia (SZ) in both animal models and human patients. However, the recent failure of Phase III clinical trials dealt a huge blow to the sc...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Li ML,Hu XQ,Li F,Gao WJ

更新日期：2015-07-03 00:00:00

abstract：:In the present study, we tested the hypothesis that the potent and selective dopamine-β-hydroxylase (DβH) inhibitor nepicastat would have minimal effects on cardiovascular and pharmacokinetic parameters associated with cocaine administration and would reduce the positive subjective effects produced by cocaine. We cond...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： De La Garza R 2nd,Bubar MJ,Carbone CL,Moeller FG,Newton TF,Anastasio NC,Harper TA,Ware DL,Fuller MA,Holstein GJ,Jayroe JB,Bandak SI,Reiman KZ,Neale AC,Pickford LB,Cunningham KA

更新日期：2015-06-03 00:00:00

abstract：:Numerous studies have shown that neurological changes are important findings of tinnitus patients. Previous studies on tinnitus have indicated that patients with pulsatile tinnitus (PT) often show altered baseline brain activity in the resting state. This study used resting-state functional magnetic resonance imaging ...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Han L,Zhaohui L,Fei Y,Pengfei Z,Ting L,Cheng D,Zhenchang W

更新日期：2015-06-03 00:00:00

abstract：:The aim of the present study was to investigate the relevance of different parameters of 3,4-methylenedioxymethamphetamine (MDMA) use, including age of first use, cumulative lifetime dose and highest daily dose for predicting cognitive performance and self-reported psychopathology. Moreover, interactions between those...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wagner D,Adolph S,Koester P,Becker B,Gouzoulis-Mayfrank E,Daumann J

更新日期：2015-04-03 00:00:00

abstract：BACKGROUND:Schizophrenia is a mental disorder characterized by impairments in diverse thinking and emotional responses, which are related to social perception dysfunction. This fMRI study was designed to investigate a neurobiological basis of social perception deficits of patients with schizophrenia in various social s...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Shin JE,Choi SH,Lee H,Shin YS,Jang DP,Kim JJ

更新日期：2015-04-03 00:00:00

abstract：RATIONALE:The endocannabinoid system has been implicated in the neurobiological mechanism underlying drug addiction, especially the primary rewarding dopamine-dependent processes. Therefore, endocannabinoid receptor antagonists, such as the CB1 cannabinoid antagonist rimonabant, have been proposed as candidates for pre...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Marinho EA,Oliveira-Lima AJ,Santos R,Hollais AW,Baldaia MA,Wuo-Silva R,Yokoyama TS,Takatsu-Coleman AL,Patti CL,Longo BM,Berro LF,Frussa-Filho R

更新日期：2015-04-03 00:00:00

abstract：BACKGROUND:Functional magnetic resonance imaging (fMRI) studies in major depressive disorder (MDD) have revealed cortical-limbic-subcortical dysfunctions during working memory (WM) processing, but the results are inconsistent and it is unclear to what extent these findings are influenced by demographic, clinical charac...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wang XL,Du MY,Chen TL,Chen ZQ,Huang XQ,Luo Y,Zhao YJ,Kumar P,Gong QY

更新日期：2015-01-02 00:00:00

abstract：BACKGROUND:Patients with schizophrenia using antipsychotics often develop metabolic side effects, especially with clozapine. Previous studies indicated that antipsychotics could activate the pathway of the sterol regulatory element-binding protein (SREBP). The sterol regulatory element binding transcription factor 2 (S...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Yang L,Chen J,Liu D,Yu S,Cong E,Li Y,Wu H,Yue Y,Zuo S,Wang Y,Liang S,Shi Y,Shi S,Xu Y

更新日期：2015-01-02 00:00:00

abstract：:Bipolar disorder (BD) is a chronic psychiatric illness of which the pathophysiology remains partially unknown. Abnormalities of neurotrophins and other trophic factors orchestrate important alterations which could be implicated in the etiology of BD. Therefore, the main objective of this review is to examine the recen...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Scola G,Andreazza AC

更新日期：2015-01-02 00:00:00

abstract：:Epidemiological studies suggest that perinatal complications, particularly hypoxia-related ones, increase the risk of schizophrenia. Recent genetic studies of the disorder have identified several putative susceptibility genes, some of which are known to be regulated by hypoxia. It can be postulated therefore that birt...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Wakuda T,Iwata K,Iwata Y,Anitha A,Takahashi T,Yamada K,Vasu MM,Matsuzaki H,Suzuki K,Mori N

更新日期：2015-01-02 00:00:00

abstract：UNLABELLED:The aims of this study were to identify gray matter (GM) and white matter (WM) volume abnormalities in pediatric obsessive-compulsive patients, to examine their relationship between these abnormalities and the severity of disorder, and to explore whether they could be explained by the different symptom dimen...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Lázaro L,Ortiz AG,Calvo A,Ortiz AE,Moreno E,Morer A,Calvo R,Bargallo N

更新日期：2014-10-03 00:00:00

abstract：:In people with schizophrenia, cognitive abilities - including memory - are strongly associated with functional outcome. Long-term potentiation (LTP) is a form of neuroplasticity that is believed to be the physiological basis for memory. It has been postulated that antipsychotic medication can impair long-term potentia...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Price R,Salavati B,Graff-Guerrero A,Blumberger DM,Mulsant BH,Daskalakis ZJ,Rajji TK

更新日期：2014-10-03 00:00:00

abstract：:The olfactory system is involved in sensory functions, emotional regulation and memory formation. Olfactory bulbectomy in rat has been employed as an animal model of depression for antidepressant discovery studies for many years. Olfaction is impaired in animals suffering from chronic stress, and patients with clinica...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Yuan TF,Slotnick BM

更新日期：2014-10-03 00:00:00

abstract：:An association between serotonin 2A receptor (5-HT2AR), encoded by HTR2A gene, and major depressive disorder (MDD) has been suggested. Here, we combined preclinical and ecological clinical approaches to explore the impact of impaired 5-HT2AR-mediated transmission on MDD or anxio-depressive-like phenotype in mice. Htr2...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Petit AC,Quesseveur G,Gressier F,Colle R,David DJ,Gardier AM,Ferreri F,Lépine JP,Falissard B,Verstuyft C,Guiard BP,Corruble E

更新日期：2014-10-03 00:00:00

abstract：INTRODUCTION:Bipolar disorder (BD) patients present a 3-5 fold greater risk of developing type 2 diabetes (T2D) compared to general population. The underlying mechanisms for the increased prevalence of T2D in BD population are poorly understood. OBJECTIVES:The purpose of this review is to critically review evidence su...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Sharma AN,Bauer IE,Sanches M,Galvez JF,Zunta-Soares GB,Quevedo J,Kapczinski F,Soares JC

更新日期：2014-10-03 00:00:00

abstract：:The present study aims to evaluate the effects of pterostilbene on lipopolysaccharide (LPS)-induced learning and memory impairment as well as the possible changes of microglia and neurons. Firstly, learning and memory function was investigated by behavioral tests. Pterostilbene attenuated LPS-induced learning and memo...

journal_title：Progress in neuro-psychopharmacology & biological psychiatry

authors： Hou Y,Xie G,Miao F,Ding L,Mou Y,Wang L,Su G,Chen G,Yang J,Wu C

更新日期：2014-10-03 00:00:00